Haematologica 2005.
90: 988-990.
Gunby, R. H., Tartari,
C. J., Porchia, F., Donella-Deana, A., Scapozza, L., and Gambacorti-Passerini,
C.
The discovery of novel anti-cancer drugs
targeting anaplastic lymphoma kinase (ALK), an oncogenic tyrosine kinase,
raises the need for in vitro assays suitable for screening compounds for ALK
inhibition. To this aim we have developed and optimized an ALK-specific
enzyme-linked immunosorbent assay that employs a novel ALK peptide substrate
and purified ALK kinase domain.
Key words: ALCL, ALK, kinase assay, inhibitor screening
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